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KMID : 0381919970270020145
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Korean Journal of Microscopy
1997 Volume.27 No. 2 p.145 ~ p.153
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Histopathological and Fine Structural Changes in Mouse Skin after Injection of Honeybee Venom
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Shin Sang-Hee
Jeong Moon-JIn
Moon Myung-Jin
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Abstract
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Histopathological and fine structural changes in mouse skin after injection of venoms extracted from the venom glands of the honeybee, Apis mellifera, were studied with light and electron microscopes. At this experiment the venoms were directly injected at the hairless abdominal skin of the mouse through the sting of the bee’s venomous organ. Main changes appeared within one hour after injection at both epithelial and connective tissues as considerable hyperemia and angioedema, and slight edema and fibrosis. High magnified electron micrographs reveal not only increase of diameter but also deposition of electron dense grains (which seems to be an auto immunoglobulin) at the collagenous fibers characteristically. This kinds of histological and fine structural responses were diminished from 12 hour after injection, and the pathological symptoms disappeared within 3 days at most cases. So, the skin responses induced by honeybee venom seem to be not severe compare to other cases reported by other venomous arthropods.
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KEYWORD
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Histopathology, Fine structure, Honeybee venom, Mouse skin
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